Next-Generation
Molecular Physics
The proprietary compute engine powering LatticeZero. Bridging fundamental geometric physics with hardware-accelerated drug discovery.
Physics, Not Pattern Matching
The RFT Architecture
Three foundational advances that enable physics-accurate molecular scoring at speeds previously impossible.
Advanced Geometric Discretization
Standard docking relies on inefficient Cartesian grids. RFT utilizes proprietary spatial packing mathematics to evaluate continuous protein pockets with maximum volumetric efficiency. This eliminates dead-space computation and enables sub-angstrom conformational searches.
Unified Energy Decomposition
Rather than patching together disconnected empirical penalties, the RFT engine evaluates 14 distinct physical interactions — including precise coordination geometries and second-shell hydrophobic effects — derived from a unified mathematical foundation.
Bare-Metal GPU Parallelization
The RFT engine was designed natively for matrix parallelization, allowing complex energy tensor calculations to execute entirely client-side via WebGPU compute shaders at rates exceeding 4,000 ligands per second. No server queue. No cloud cost.
Proven on Standard Datasets
Validated against DEKOIS2 with property-matched decoys. Every result includes holdout cross-validation and Y-scramble null controls.
| Target | Family | Validated AUC |
|---|---|---|
| HMGR | Reductase | 0.980 |
| PDE5 | Phosphodiesterase | 0.883 |
| Neuraminidase | Glycosidase | 0.875 |
| MCL1 | Apoptosis Regulator | 0.868 |
| ESR1 | Nuclear Receptor | 0.858 |
| ADRB2 | GPCR | 0.834 |
| CATL | Cysteine Protease | 0.829 |
Validated via 5-fold cross-validation with Y-scramble null controls. All AUC values are holdout-validated on DEKOIS 2.0 with property-matched decoys.
Experience the Engine
The RFT engine is available exclusively through the LatticeZero platform.
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